The Pre-stack depth migration (PSDM) technology is recognized as the effective way to resolve the seismic imaging of complex geological structures. Different special PSDM technology is needed according to different geological settings. The seafloor is rough with a series of deep canyons and the seismic imaging underlying is distorted. To solve these problems, the special PSDM technologies are used. The pre-stack depth migration from the sea surface is used to get the accurate seafloor images. The initial velocity model is made with the controlled velocity inversion (CVI) technology and the main faults are added to the model. Then a velocity scanning analysis is introduced and the velocity model converges quickly. The Kirchhoff integral migration method is used to perform the PSDM. These researches were applied in Panyu-Liuhua region in Pearl River Mouth Basin and got achievement, which reveals that the influences of rough seafloor are essentially removed and the imaging of faults and seismic layers is improved as a consequence of some structural traps validated.