An integrated method of predicting the distribution of effective source rocks is proposed for the sedimentary basin with low- to middle-degree exploration. The basic idia is that combining well data with seismic data, the method includes five procedures from site to area and from profile to plane as follows: a) ascertaining the favorable sedimentary facies zone; b) ascertaining the distribution of source rock in plane; c) zoning the distribution of the sedimentary facies in region; d) ascertaining the distribution of thermal evolution in plane; and e) predicting the distribution of efficient source rocks. This method is successfully applied to predict the distribution of efficient source rocks in the Jurassic SQ1 sequence in a basin, North Yellow Sea, which is still during low- to middle-degree of exploration.