The Lower Cambrian Niutitang shale is wide and stably distributed in northwestern Guizhou. It consists of deep-water shelf carbonaceous shale and shallow-water shelf silty shale with large sedimentary thickness (﹥39m), in which the black carbonaceous shale at the bottom of Niutitang Formation is organic-rich. Organic geochemical analysis shows that it is characterized by predominant Type-Ikerogen, high TOC values (TOC >5, in the organic-rich black shale) and high mature to overmature organic matter in thermal evolution. Microfractures and micropores are developed in the shale reservoirs, which are of relatively high porosity(mean 5.14,) and permeability(mean 0.0114×10-3μm2). The high content of gas(1.3m3/t in average) means a good potential of shale gas resources. It is predicted that Jinsha-Xifeng and Renhuai areas are potential for shale gas prospecting.