There is a large difference in wave impedance between the Ordovician carbonate karst stratum and the mudstone of the Sandamu Formation in the TZ62 well area of Tarim Basin. As a result, the fractured and porous reservoirs with weak amplitude reflection which developed in the lower part of the weathered crust are blocked by the strong reflection of the lithologic interface, and it is difficult to predict this type of reservoirs by conventional amplitude. Through building three types of geological model, including stratigraphic framework model, the stratigraphic framework mosaicking reservoir model and the mosaicing reservoirs model after removing the lithologic top interface, the reservoirs with different types of stratigraphic structure and different locations are simulated by forward modeling. The forward seismic data are decomposed into several components by using the karst reservoir prediction technology based on waveform decomposition, and each component reflects the strata with similar physical properties, then the weak amplitude reservoir can be predicted by extracting the target component. The effectiveness of this technology is verified by applying in TZ62 well area of Tarim Basin and by analyzing the actual production data of oilfield.