Based on the data of seismic, logging and analysis, and the removal of the later structural influence, the sedimentary paleogeomorphology of Zhujiang Formation in Panyu Area is restored by considering the factors of decompression correction and paleobathymetry correction, and the influence of paleogeomorphology on the deposition of Zhujiang Formation is analyzed through sedimentary forward simulation. The results show that: (1) The method of using the top and bottom structural surface of the target layer after drilling depth correction to obtain the true thickness of the formation is more convenient and practical, and the restored result after well-seismic combination is more accurate; (2) The original formation thickness of the target layer can be restored more accurately by decompression correction according to different lithology; (3) The sedimentary palaeogeomorphology of Zhujiang Formation in Panyu area is characterized by high in the northeast and east, low in the southwest and south, and gentle in the whole. The micro fluctuation feature of the paleogeomorphology controls the microfacies distribution in the wave-dominated braided river delta; (4) When the paleogeomorphic parameters are consistent with the actual restoration results, the plane distribution of lithologic types of sedimentary process simulation can be well matched with the sedimentary strata.