China's oil companies have several oil and gas cooperation projects in the east of Lekhwair Uplift of the foreland basin on the west side of Oman Mountain, Middle East. Due to the lower degree of regional exploration, the analysis of structure-faults and hydrocarbon accumulation was not deep enough, which restricts the regional exploration process. Based on the new well and seismic data, this paper carried out system structural interpretation and analysis of hydrocarbon accumulation. The results show that: (1) Once being in a regional tensile environment during Triassic-Jurassic, the Lekhwair Uplift is a reverse anticline developed in Late Cretaceous mainly under the control of the rapid uplift and compression of the Oman Mountain, and the overlying Paleogene is directly draped over the Middle Cretaceous in angular unconformity contact in the uplift area. (2) Two sets of high-angle normal faults developed in the uplift area, the different scale faults appear as Y-shape or composite Y-shape forming graben-horst structure on section, and as X-shape distribution in the plane. In Late Cretaceous, these faults are in a closed state due to the orogenic compression. (3) This region was in the passive continental margin for a long time in the Mesozoic era, and the temporal -spatial configuration of source, reservoir and cap is good. The study area has three typical reservoir forming models, namely, the Lower Cretaceous Shuaiba reef-shoal lithologic reservoir, the Upper Cretaceous Natih fault-block reservoir and stratigraphic unconformity reservoir, and the Paleogene Umm er Radhuma bioclastic limestone reservoir. The two sets of main source rock, Diyab Formation of Upper Jurassic and Bab Formation of Lower Cretaceous, have entered a mature stage since Late Cretaceous, then unconformity and vertical faults constitute an important oil and gas conducting system in the region, promoting regional oil and gas accumulation. It is believed that the top and west slope of Lekhwair Uplift have similar geological conditions with those in the east, so they have larger exploration potential and are important exploration directions in the future.